Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Shiitake mushrooms (Lentinula edodes) have been investigated for their potential benefits in oral health, particularly for gingivitis. Several in vitro and clinical studies suggest that extracts from shiitake mushrooms possess antimicrobial properties against oral pathogens, including Streptococcus mutans and Porphyromonas gingivalis, which are implicated in the development of gingivitis and periodontal disease. A small randomized controlled trial (Nile et al., 2015, Journal of Clinical and Diagnostic Research) demonstrated that a mouth rinse containing shiitake extract was comparably effective to chlorhexidine in reducing plaque and gingival inflammation over a short period, although the sample size and duration were limited. The purported mechanisms involve the mushroom's polysaccharides, such as lentinan, and other bioactive compounds that may inhibit bacterial adherence and modulate inflammatory responses. However, while these preliminary findings are promising, the overall quality and quantity of evidence remain modest. There is a lack of large-scale, long-term clinical trials, and most data derive from small human studies or laboratory research. Therefore, although there is some scientific rationale and early clinical support for the use of shiitake in managing gingivitis, its efficacy is not yet firmly established, warranting a moderate-low evidence rating.

More about Shiitake
More about Gingivitis

Other ingredients used for Gingivitis

Other health conditions supported by Shiitake

Products containing Shiitake