Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in many fruits and vegetables, has gained attention for its potential benefits in oral health, particularly in the context of gingivitis. The scientific rationale for quercetin's use in managing gingivitis centers on its anti-inflammatory, antioxidant, and antibacterial properties. Several in vitro studies have demonstrated that quercetin can inhibit the production of pro-inflammatory cytokines (such as IL-1β, IL-6, and TNF-α) by gingival fibroblasts and other oral cells. This suggests a potential to reduce the inflammatory response characteristic of gingivitis. Additionally, quercetin has shown antibacterial activity against common oral pathogens like Porphyromonas gingivalis and Streptococcus mutans, which are implicated in plaque formation and gingival inflammation.

Animal studies and a limited number of small clinical trials further suggest that topical or systemic administration of quercetin may reduce gingival inflammation, decrease bleeding on probing, and improve certain markers of periodontal health. However, the overall quality and quantity of clinical evidence remain low, with most studies being preliminary, small-scale, or lacking rigorous controls. As such, while there is a clear scientific basis for studying quercetin in the context of gingivitis, its clinical efficacy is not yet established, and more robust human trials are needed. Thus, the evidence rating is moderate to low (2/5), reflecting promising but not yet definitive scientific support.

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