Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonones are a subclass of flavonoids, which are polyphenolic compounds widely found in citrus fruits and other plants. Their use in supporting the management of gingivitis is primarily supported by scientific evidence, though the strength of the evidence is moderate. Flavonones, particularly those like naringenin and hesperidin, have demonstrated anti-inflammatory, antioxidant, and antimicrobial properties in laboratory and animal studies. These effects are relevant to gingivitis, a common inflammatory condition of the gums caused by bacterial plaque.

Several in vitro studies report that flavonones can inhibit the growth of pathogenic oral bacteria and modulate inflammatory responses in gingival tissues. Some small clinical trials and pilot studies have evaluated mouthwashes or toothpastes containing citrus flavonones, noting reductions in gingival inflammation and bleeding when compared to placebo. For example, hesperidin and naringin have been found to inhibit pro-inflammatory cytokines and reduce oxidative stress in gingival cells. However, large-scale, long-term randomized controlled trials in humans are limited, and most studies have been of short duration or have combined flavonones with other active ingredients, making it difficult to attribute effects solely to flavonones.

In summary, there is scientific evidence—primarily from laboratory and early clinical studies—suggesting that flavonones may help reduce gingival inflammation and support oral health, but more robust human research is needed to confirm their efficacy for gingivitis.

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Other ingredients used for Gingivitis

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