Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dehydrocholic acid is a synthetic bile acid derivative that has been used in clinical practice, particularly in Europe, for the treatment of certain biliary disorders. Its use is primarily based on its choleretic properties—meaning it increases bile secretion. Historically, dehydrocholic acid has been prescribed to support bile flow in cases of biliary dyskinesia (sluggish gallbladder function), cholestasis, and after cholecystectomy (gallbladder removal) to aid digestion and alleviate symptoms like indigestion and bloating.

Some studies from the mid-20th century and later have demonstrated that dehydrocholic acid can increase bile secretion and alter bile composition, potentially helping to prevent bile stasis and related complications. However, modern, high-quality randomized controlled trials are lacking. The evidence supporting its use is largely based on older, small-scale clinical reports and observational studies rather than robust, contemporary clinical trials.

Dehydrocholic acid is still listed in some pharmacopeias and is available in certain countries as a treatment for biliary disorders, but its clinical use has declined with the advent of more effective and better-studied agents (like ursodeoxycholic acid). In summary, there is some scientific basis for its use in supporting gallbladder function or compensating for its removal, but the strength of evidence is limited and not considered strong by modern standards.

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