Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Neem (Azadirachta indica) has a long history of use in traditional medicine systems, particularly in Ayurveda and Unani medicine, for the management of fever. In these traditions, neem leaves, bark, and extracts are commonly used as part of herbal formulations intended to reduce body temperature and manage symptoms associated with various febrile illnesses, including malaria and viral infections. The rationale is based on neem’s reputed antipyretic (fever-reducing) and anti-inflammatory properties.

From a scientific perspective, there is limited but suggestive evidence for neem’s antipyretic effects. Some animal studies have demonstrated that neem leaf extracts can reduce fever in induced models, possibly due to the presence of compounds such as nimbidin and azadirachtin, which exhibit anti-inflammatory and immunomodulatory activities. However, robust clinical trials in humans validating these effects are lacking, and the available studies are generally of low methodological quality or conducted in vitro or in animal models only.

In summary, neem’s use for fever is primarily justified by centuries of traditional practice, with some preliminary scientific support but insufficient evidence for definitive clinical recommendations. Its widespread use in traditional medicine highlights its cultural importance, but more research is needed to confirm its efficacy and safety for fever management in humans.

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