Clerodendrum phlomidis, known as Arni or Bhandari, has been traditionally used in Ayurvedic and folk medicine, particularly in India, for the treatment of fever. The leaves, roots, and bark of the plant are commonly utilized in decoctions or powders in traditional remedies. The primary basis for its use in fever is historical and cultural, as documented in classical Ayurvedic texts and ethnobotanical literature. Clerodendrum phlomidis is often mentioned as an ingredient in polyherbal formulations used to reduce fever and manage associated symptoms like inflammation and malaise.

Scientific evidence supporting its antipyretic (fever-reducing) activity is limited but present. Some preclinical studies have reported that extracts of Clerodendrum phlomidis exhibit antipyretic effects in animal models, such as yeast-induced pyrexia in rats. These effects are attributed to the presence of flavonoids, saponins, and other phytochemicals with potential anti-inflammatory and antioxidant properties. However, the quality and quantity of clinical research in humans are lacking, and there are no large-scale, high-quality trials confirming its efficacy or safety for fever management in humans. Therefore, while some scientific studies offer preliminary support, the use of Clerodendrum phlomidis for fever is primarily justified by traditional practice, with the available evidence rated at 2 due to the lack of robust clinical validation.