Clerodendrum indicum, commonly known as "turk's turban" or "skyrocket," has a long-standing history of use in traditional medicine systems, particularly in South and Southeast Asia. It has been employed to treat a variety of ailments, including fever. Traditional healers often use decoctions or infusions made from the roots, leaves, or stems of the plant as antipyretic agents to help reduce fever. The rationale for its use is primarily based on empirical observations and ethnomedicinal practices rather than rigorous scientific validation.

A few ethnobotanical surveys and reports from regions such as India and Bangladesh document the use of Clerodendrum indicum in managing fever among other conditions. However, scientific studies supporting this use are limited. There are some in vitro and animal studies indicating the plant's extracts may possess anti-inflammatory and antioxidant properties, which could potentially contribute to fever reduction. For example, some research has demonstrated that extracts from Clerodendrum species can inhibit inflammatory mediators, which might explain the traditional antipyretic claims. Nevertheless, there is a lack of robust clinical trials or pharmacological studies directly confirming its efficacy and safety for treating fever in humans.

In summary, the evidence for using Clerodendrum indicum to treat fever is primarily traditional, with a modest level of scientific plausibility but insufficient direct clinical validation. Therefore, its use is best regarded as supported by tradition rather than strong scientific evidence.