Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Citrus nobilis, commonly known as Mandarin orange, has been used in traditional medicine systems—especially in various regions of Asia—for the management of fever and related symptoms. The use of Citrus nobilis peels, leaves, or fruit in remedies for fever is documented in ethnobotanical surveys and traditional Chinese medicine (TCM) texts, where it is thought to help "clear heat" and support overall body cooling. However, this use is mostly based on historical and cultural practices rather than robust scientific inquiry.

There is minimal direct scientific evidence to support the effectiveness of Citrus nobilis specifically for the treatment of fever. While some in vitro and animal studies have investigated the fruit's phytochemical constituents—such as flavonoids, limonoids, and essential oils—for their general anti-inflammatory or antimicrobial properties, there is a lack of controlled clinical trials or mechanistic studies directly linking Citrus nobilis to fever reduction in humans. Thus, the continued use of Citrus nobilis for fever is primarily justified by tradition rather than scientific validation.

In summary, while historical and ethnobotanical records support its traditional use for fever, the evidence quality is low, and there is currently no substantial scientific backing for its efficacy in this specific condition.

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