Evidence supporting the use of: Zinc
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Zinc is increasingly being investigated for its potential role in supporting or treating non-alcoholic fatty liver disease (NAFLD). A growing body of scientific literature suggests that zinc may have beneficial effects on liver health, primarily due to its antioxidant, anti-inflammatory, and insulin-sensitizing properties. Several preclinical studies in animal models of fatty liver disease have shown that zinc supplementation can reduce hepatic steatosis, decrease oxidative stress, and improve liver function tests. These effects are thought to be due to zinc’s role in modulating lipid metabolism, reducing inflammatory cytokines, and improving insulin resistance—key factors in the pathogenesis of NAFLD.
Human evidence, however, remains limited. A few small clinical trials and observational studies have reported lower serum zinc levels in patients with NAFLD compared to healthy controls, and some pilot supplementation studies have demonstrated improvements in liver enzymes and markers of inflammation. Nonetheless, these studies are generally small, have short durations, and often lack robust control groups. Major liver society guidelines do not currently recommend zinc as a standard treatment for fatty liver disease, citing insufficient high-quality evidence.
In summary, while there is some scientific rationale and early-stage experimental evidence suggesting zinc may benefit patients with fatty liver disease, the clinical evidence is not yet strong. Its use can be considered experimental and should not replace established treatments such as dietary modification, exercise, and management of metabolic risk factors.
Other ingredients used for Fatty Liver Disease
akkermansia muciniphilaalgal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
Eicosapentaenoic Acid
Rhubarb
walnut
Zucchini
Other health conditions supported by zinc
AbrasionsAcne
Acquired Immune Deficiency Syndrome
Aging (prevention)
Alcoholism
Anemia
Anorexia
Antibiotics (alternatives to)
Anxiety
Anxiety Disorders
Appetite (deficient)
Arthritis
Athlete's Foot
Attention Deficit Disorder
Autism
Autoimmune Disorders
Benign Prostate Hyperplasia
Birth Defects (prevention)
Bites and Stings
Blisters
Body Building
Body Odor
Boils
Broken Bones
Bruises (healing)
Bulimia
Burns and Scalds
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Canker Sores
Carbuncles
Cardiovascular Disease
Cartilage Damage
Cataracts
Celiac Disease
Cervical Dysplasia
Chemotherapy (reducing side effects)
Cholera
Cirrhosis of the Liver
Cold Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Colitis
Concentration (poor)
Congestion
Congestive Heart Failure
Conjunctivitis
Contagious Diseases
Convalescence
Copper Toxicity
Cough (damp)
Cough (dry)
Cough (general)
Cough (spastic)
Cradle Cap
Cramps (menstrual)
Crohn's Disease
Cuts
Cystic Fibrosis
Dandruff
Debility
Dehydration
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Diaper Rash
Diarrhea
Digestion (poor)
Duodenal Ulcers
Dysentery
Eczema
Endometriosis
Energy (lack of)
Enteritis
Epstein Barr Virus
Erectile Dysfunction
Exercise
Eye Infections
Eye Problems
Eyes (red or itching)
Eyes (spots before)
Eyesight (poor)
Failure to Thrive
Fat Metabolism (poor)
Fatty Liver Disease
Fibrosis
Fingernails (weak or brittle)
Foot Odor
Free Radical Damage
Gastritis
Giardia
Gingivitis
Hair (loss or thinning)
Hair Care (general)
Halitosis
Hashimoto's Disease
Hearing Loss
Heart (weakness)
Heavy Metal Poisoning
Hemochromatosis
Hemorrhoids
Hepatitis
Herpes
Hypothyroid
Impetigo
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Insomnia
Irritability
Irritable Bowel Syndrome
Itching
Itching (rectal)
Jock Itch
Labor and Delivery
Lead Poisoning
Leaky Gut Syndrome
Leprosy
Lesions
Leucorrhea
Liver Detoxification
Lupus
Macular Degeneration
Mastitis
Measles
Memory and Brain Function
Menorrhagia
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mononucleosis
Mood Swings
Nerve Damage
Nervous Exhaustion
Night Blindness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pancreatitis
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Poison Ivy or Oak
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Premature Ejaculation
Progesterone (low)
Prostatitis
Protein Digestion (poor)
Psoriasis
Puberty (hormone balancer)
Rashes and Hives
Rhinitis
Rosacea
Scars / Scar Tissue
Schizophrenia
Scratches and Abrasions
Seborrhea
Sex Drive (low)
Shingles
Sickle Cell Anemia
Sinus Infection
Skin (dry and/or flaky)
Skin (infections)
Skin (oily)
Skin Care (general)
Sleep (restless and disturbed)
Small Intestinal Bacterial Overgrowth
Smell (loss of)
Sore or Geographic Tongue
Sore Throat
Stress
Stye
Sugar Cravings
Sunburn
Surgery (healing from)
Surgery (preparation for)
Syphilis
Teeth (loose)
Testosterone (low)
Thinking (cloudy)
Tickle in Throat
Tonsillitis
Tooth Decay
Toxemia
Triglycerides (high)
Tuberculosis
Ulcerations (external)
Ulcers
Vitiligo
Warts
Wasting
Worry
Wounds and Sores
Products containing zinc
Nature's Sunshine Love and Peas (Sugar Free)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AnxiousLess
Nature's Sunshine AnxiousLess
Nature's Sunshine Bowel Detox
Nature's Sunshine Calcium-Magnesium (SynerPro)
Nature's Sunshine Candida Clear
Nature's Sunshine Cellular Energy
Nature's Sunshine Children's Elderberry Immune
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Defense Maintenance
Nature's Sunshine Dieter's Cleanse
Nature's Sunshine Glandular System
Nature's Sunshine Love and Peas
Nature's Sunshine Master Gland Formula®
Nature's Sunshine Mega-Chel
Nature's Sunshine Men's Formula (With Lycopene)
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Perfect Eyes
Nature's Sunshine Power Greens
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal
Nature's Sunshine Power Meal
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Immune
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Target TS-II Formula
Nature's Sunshine Thyroid Support
Nature's Sunshine Ultrabiome DTX
Nature's Sunshine VitaWave
Nature's Sunshine Yeast/Fungal Detox
Nature's Sunshine Zinc
Nature's Sunshine Zinc Lozenge
