Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Perilla (Perilla frutescens) is a plant commonly used in East Asian cuisine and traditional medicine. Its leaves and seeds contain bioactive compounds such as rosmarinic acid, omega-3 fatty acids (particularly alpha-linolenic acid), and flavonoids. Recent preclinical studies have explored the potential of perilla extracts in supporting liver health, including fatty liver disease (also known as hepatic steatosis). Several animal studies suggest that perilla oil supplementation may help reduce liver fat accumulation, improve antioxidant status, and modulate lipid metabolism. These effects are thought to be due to perilla’s high content of polyunsaturated fatty acids and its anti-inflammatory and antioxidative properties.

However, while there is modest scientific interest and some promising results from animal models, robust clinical trials in humans are lacking. The evidence base is therefore considered weak to moderate, primarily limited to in vitro and animal research. There is also some overlap with traditional use in East Asia for supporting general liver health, but the application specifically to fatty liver disease is a more recent, science-driven concept. Thus, perilla’s use for fatty liver disease can be described as having some scientific validation, but the current level of evidence does not yet strongly support its routine use for this condition in clinical practice.

More about perilla
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Other ingredients used for Fatty Liver Disease

Other health conditions supported by perilla

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