Evidence supporting the use of: Vitamin B12
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 is scientifically recognized as essential for normal energy production and neurological function. Fatigue is a classic symptom of vitamin B12 deficiency, which can result from inadequate dietary intake (especially in strict vegetarians/vegans), malabsorption syndromes (e.g., pernicious anemia), or certain medical conditions affecting the digestive tract. Numerous clinical studies have demonstrated that correcting vitamin B12 deficiency in affected individuals leads to significant improvements in fatigue and related symptoms. For example, a 2006 study in the "Journal of the American Geriatrics Society" showed that B12 supplementation improved fatigue and cognitive symptoms in deficient elderly patients. However, in people with normal B12 status, robust evidence does not support the use of additional B12 supplementation for fatigue. Several studies in healthy or non-deficient individuals found no benefit of B12 supplementation on energy levels or fatigue. Thus, the scientific justification for B12 in the treatment of fatigue is strong, but primarily limited to cases of confirmed deficiency. Routine supplementation in the absence of deficiency is not supported by current evidence. In summary, vitamin B12 is an effective treatment for fatigue due to deficiency, but does not alleviate fatigue from other causes.

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Other ingredients used for Fatigue

acai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
adrenal cortex
alfalfa
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
apple
arjun tree
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asparagus
aspartic acid
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barley
beet
bergamot
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beta-alanine
betel
bifidobacterium breve
black cumin
black garlic
sesame
black tea
bonito peptide
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bovine heart
bovine kidney
bovine liver
bovine spleen
branched-chain amino acids
rice
bupleurum falcatum
burdock
caffeine
cat's claw
caterpillar mushroom
chaga mushroom
chen pi
chia seed
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chlorella
chokeberry
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
damiana
DHEA (dehydroepiandrosterone)
eleuthero
fennel
fenugreek
fish protein
folate
fruit and vegetable blend (proprietary)
fu ling
ginseng
gooseberry
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greek mountain tea
green tea
guarana
guayusa
hibiscus
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knotweed
jujube
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l-cysteine
l-glycine
l-leucine
l-ornithine
l-taurine
l-tyrosine
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lactoferrin
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