Evidence supporting the use of: Flaxseed
For the health condition: Estrogen (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flaxseed (Linum usitatissimum) is often discussed in the context of estrogen support due to its high content of lignans, a type of phytoestrogen. Phytoestrogens are plant-derived compounds with structural similarity to estradiol, the primary female sex hormone. When consumed, lignans can be converted by intestinal bacteria into enterolignans (enterodiol and enterolactone), which can bind to estrogen receptors and exert weak estrogenic or anti-estrogenic effects depending on endogenous estrogen levels.

Several small clinical studies and animal studies suggest that flaxseed may modestly influence estrogen metabolism and hormone balance, particularly in postmenopausal women. Some research has found that flaxseed supplementation can increase the ratio of 2-hydroxyestrone to 16α-hydroxyestrone, a change associated with a lower risk of certain estrogen-dependent cancers. However, the ability of flaxseed to raise circulating estrogen levels in humans with low estrogen is not well established. Most evidence points to a modulatory effect rather than a straightforward increase in estrogen.

Overall, while there is a biological rationale and some early evidence for flaxseed influencing estrogen activity, high-quality studies directly supporting its use for the treatment of low estrogen are limited. Thus, the scientific evidence is considered weak to moderate (rated 2/5), and flaxseed should not be relied on as a sole therapy for estrogen deficiency. Further research is needed to clarify its efficacy and safety in this context.

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