Evidence supporting the use of: DHEA (dehydroepiandrosterone)
For the body system: Estrogen

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is a steroid hormone produced by the adrenal glands, serving as a precursor to both androgens and estrogens, including estradiol. Its use to support the estrogen body system is based on its role as a substrate for estrogen biosynthesis, particularly in postmenopausal women, where endogenous estrogen levels decline. Several clinical trials and reviews have assessed DHEA supplementation, especially in the context of menopausal symptoms, vaginal atrophy, and infertility related to diminished ovarian reserve.

Some studies have shown that DHEA supplementation can modestly increase circulating estrogen levels and improve certain menopausal symptoms such as vaginal dryness and decreased libido. For example, intravaginal DHEA has been found to improve symptoms of vulvovaginal atrophy in postmenopausal women, likely due to local conversion to estrogens and androgens. In reproductive endocrinology, DHEA supplementation has been investigated in women with diminished ovarian reserve, with mixed results regarding its impact on estrogen levels and pregnancy outcomes.

However, while there is biological plausibility and some supportive clinical evidence, the data are not uniformly strong or conclusive. Large-scale, high-quality randomized controlled trials are limited, and the long-term safety of DHEA supplementation remains uncertain. As such, the evidence for DHEA supporting the estrogen system is moderate (rated 3 out of 5), with best support for use in specific clinical settings rather than general population supplementation.

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