There is some scientific evidence suggesting that Vitamin E, including mixed tocotrienols, may have beneficial effects on eczema (atopic dermatitis), although the evidence is limited and not conclusive. Vitamin E is known for its antioxidant and anti-inflammatory properties, which are thought to help reduce oxidative stress and inflammation associated with eczema. Some small clinical studies and trials have reported improvements in eczema symptoms with oral or topical Vitamin E supplementation. For example, a double-blind, placebo-controlled study published in the International Journal of Dermatology (2015) showed that oral Vitamin E supplementation led to significant improvements in eczema severity scores compared to placebo. However, most studies do not specifically use mixed tocotrienols but rather alpha-tocopherol, the most common form of Vitamin E in supplements.

Research on tocotrienols is more limited, but some in vitro and animal studies suggest they may have stronger antioxidant effects than tocopherols. Nonetheless, robust clinical trials examining tocotrienols specifically for eczema are lacking. Systematic reviews generally conclude that Vitamin E may be helpful as an adjunct therapy for eczema, but more high-quality, large-scale human studies are needed to confirm efficacy, optimal dosing, and safety.

In summary, while the scientific rationale and some preliminary evidence support the use of Vitamin E for eczema, especially for its anti-inflammatory properties, the evidence level is low and not yet definitive, particularly for mixed tocotrienols.