Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (primarily as alpha-tocopherol) is occasionally used as a supportive treatment for eczema (atopic dermatitis), justified by some scientific investigation. Several small clinical studies and randomized controlled trials have reported that oral vitamin E supplementation may help reduce eczema severity and symptoms such as itching and inflammation. The proposed mechanism involves vitamin E’s antioxidant and anti-inflammatory properties, which may help protect skin barrier function and decrease oxidative stress implicated in eczema pathogenesis.

A 2015 double-blind randomized controlled trial published in International Journal of Dermatology (Jaffary et al.) found that 400 IU/day of oral vitamin E for 8 months significantly improved eczema symptoms compared to placebo. Other small studies have demonstrated similar benefits, but these are limited by small sample sizes, short durations, and variable dosing regimens. There is also some preclinical evidence that vitamin E can modulate immune responses and reduce inflammatory cytokines.

Despite these findings, the quality of evidence remains low to moderate. Systematic reviews note that while there is some promise, larger and more robust clinical trials are needed to confirm efficacy and safety. Topical vitamin E has also been tried, but results are inconsistent, and allergic contact dermatitis to vitamin E itself can occur. Overall, vitamin E is not a first-line eczema therapy, but there is some scientific basis for its adjunctive use.

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