Vitamin E, including its delta-tocopherol form, has been explored for its potential benefits in managing eczema (atopic dermatitis), primarily due to its antioxidant and anti-inflammatory properties. Several small clinical studies and laboratory investigations have examined the use of vitamin E (usually as mixed tocopherols or alpha-tocopherol) in eczema. For example, a few randomized controlled trials have reported that oral vitamin E supplementation may lead to modest improvements in eczema severity scores and reduction in symptoms such as itching. The proposed mechanism is that vitamin E helps protect skin cells from oxidative stress and may modulate inflammatory pathways involved in eczema.

However, the quality and quantity of evidence are limited. Most studies involve small sample sizes, short durations, and do not focus specifically on delta-tocopherol, but rather on vitamin E as a general group. There is insufficient evidence to suggest that delta-tocopherol, as opposed to other tocopherol isoforms, has unique or superior benefits for eczema. In addition, topical vitamin E's effects remain inconclusive, as some reports suggest potential irritation in sensitive individuals.

In summary, there is some scientific evidence supporting the use of vitamin E in managing eczema, but it is not robust or specific to delta-tocopherol. Larger, high-quality trials are needed to confirm efficacy and safety. Current support for its use is based on a combination of limited clinical data and theoretical mechanisms.