Vitamin E, including its beta-tocopherol form, has been explored for its potential benefits in treating or supporting eczema (atopic dermatitis) due to its antioxidant and anti-inflammatory properties. There is some scientific interest in the use of Vitamin E, primarily in the more common alpha-tocopherol form, for skin conditions characterized by inflammation and oxidative stress, such as eczema. Several small clinical trials and animal studies suggest that oral or topical Vitamin E may help reduce eczema symptoms, such as itching and lesion severity, likely by reducing oxidative damage and modulating immune responses.

However, the evidence remains limited and somewhat inconsistent. Most studies involve small sample sizes, short durations, and often combine Vitamin E with other agents, making it difficult to isolate its specific effects. Furthermore, the majority of research focuses on alpha-tocopherol rather than beta-tocopherol, and there is a lack of robust, high-quality randomized controlled trials specifically investigating beta-tocopherol for eczema. Major clinical guidelines do not currently recommend Vitamin E as a standard therapy for eczema due to insufficient evidence.

In summary, while there is some scientific rationale and a modest amount of preliminary clinical evidence for Vitamin E's benefit in eczema, the strength of the evidence is low (rated 2/5), and further well-designed studies are needed before its routine use can be recommended.