Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Squalene is a naturally occurring lipid found in human sebum and various plant and animal oils. Its use in skincare, including for conditions like eczema (atopic dermatitis), is primarily based on its emollient and moisturizing properties. There is some scientific basis for its use: Squalene and its hydrogenated derivative, squalane, are effective skin moisturizers, helping to restore skin barrier function and reduce transepidermal water loss. This is particularly relevant for eczema, where the skin barrier is compromised and dryness is a common symptom.

However, direct clinical evidence for squalene specifically treating or improving eczema symptoms is limited. Most supporting data come from studies and reviews highlighting the importance of skin barrier restoration in eczema management, and squalene’s general role as an emollient. A few small studies suggest that squalene may have anti-inflammatory and antioxidant properties, which could theoretically benefit eczema-prone skin, but these findings have not yet translated into robust clinical recommendations for eczema treatment.

In summary, while squalene is sometimes included in moisturizers marketed for sensitive or eczema-prone skin, and its moisturizing effect is supported by basic research, there is a lack of high-quality clinical trials directly validating its effectiveness for eczema. The evidence is therefore modest but not absent, justifying a low-to-moderate rating.

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Other ingredients used for Eczema

Other health conditions supported by Squalene

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