Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sesquiterpenes are a class of naturally occurring compounds found in various plants and essential oils, such as chamomile, patchouli, and sandalwood. Their use in supporting or treating eczema is primarily rooted in traditional and folk medicine, rather than being thoroughly validated by modern scientific research. Historically, plants rich in sesquiterpenes, especially German chamomile (Matricaria recutita), have been applied topically to soothe irritated skin and manage inflammatory skin conditions, including eczema. The rationale is partly based on the observed anti-inflammatory and calming properties of these plants in traditional settings.

Scientific studies on sesquiterpenes themselves (as individual compounds) for eczema are limited. Some in vitro and animal studies suggest that certain sesquiterpenes have anti-inflammatory effects, and may inhibit mediators involved in skin inflammation. However, robust clinical trials on humans with eczema are lacking. Most evidence comes from studies on essential oils or plant extracts rather than isolated sesquiterpenes.

In summary, while there is a traditional basis for the use of sesquiterpene-rich plants and extracts in managing eczema symptoms, direct scientific validation for sesquiterpenes alone remains limited. The evidence rating reflects some promising preclinical data and longstanding traditional use, but a lack of high-quality clinical trials.

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