Portulaca oleracea (commonly known as purslane) has a long history of use in traditional medicine systems, particularly in East Asia, for a variety of skin conditions, including eczema. The plant is valued for its purported anti-inflammatory, antioxidant, and wound-healing properties. In traditional Chinese medicine, portulaca is used both topically and internally to "clear heat" and reduce inflammation associated with skin eruptions, such as those seen in eczema (also known as atopic dermatitis).

Scientific validation for the use of portulaca in eczema is limited. While several in vitro and animal studies have demonstrated that extracts of portulaca can reduce markers of inflammation and support skin barrier function, robust clinical trials in humans with eczema are lacking. A few small studies and case reports suggest some benefit when used as an adjunctive treatment, likely owing to its antioxidant content (such as omega-3 fatty acids, vitamins A and C, and flavonoids), but these findings are preliminary.

In summary, the use of portulaca for eczema is primarily rooted in traditional practice, with some emerging but insufficient scientific evidence to support its effectiveness. Larger, well-controlled clinical studies would be needed to firmly establish its role in eczema management.