Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polypodium leucotomos, a tropical fern species, has been the subject of several scientific studies, primarily for its photoprotective and anti-inflammatory properties. Its extracts are used in dermatology, most notably in the management of photoaging and prevention of photodermatoses. There is some preliminary scientific evidence supporting its use in atopic dermatitis (eczema). A few small clinical studies and case reports suggest that oral Polypodium leucotomos extract may reduce inflammation, improve skin barrier function, and decrease the severity of eczema symptoms, likely due to its antioxidant and immunomodulatory effects. For example, a 2012 study published in the "Journal of the European Academy of Dermatology and Venereology" showed modest improvement in eczema severity in treated patients. However, the number of high-quality, large-scale randomized controlled trials is limited, and most available studies have small sample sizes or lack rigorous methodology. As such, while there is emerging scientific rationale and some clinical evidence, the strength of the evidence is still considered low to moderate. More robust research is needed to fully validate Polypodium's efficacy and safety for eczema treatment. Its use is primarily supported by scientific inquiry rather than traditional medicine, as there is little record of this use in folk or traditional healing systems.

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