Polyphenols are a diverse group of naturally occurring compounds found in plants, known for their antioxidant, anti-inflammatory, and immunomodulatory properties. There is a growing body of scientific research examining the potential benefits of polyphenols for skin conditions, including eczema (atopic dermatitis). Some clinical and preclinical studies suggest that certain polyphenols—such as those from green tea (epigallocatechin gallate, EGCG), resveratrol, and curcumin—may help reduce inflammation, oxidative stress, and pruritus associated with eczema. These effects are mainly attributed to their ability to modulate signaling pathways involved in skin inflammation and barrier function.

However, most of the evidence comes from laboratory studies, animal models, or small-scale human trials. For example, topical green tea extracts and oral polyphenol-rich supplements have shown promise in reducing eczema severity in some studies, but results are not yet consistent or robust enough to warrant broad clinical recommendations. Systematic reviews note the potential but highlight the need for more high-quality, large-scale randomized controlled trials to confirm efficacy and safety.

In summary, while scientific interest and preliminary evidence exist for the use of polyphenols in eczema, the current level of evidence is limited (rated 2/5). More research is needed before polyphenols can be considered an established or primary treatment for eczema.