Oxystelma, a genus of plants in the Apocynaceae family, is referenced in some systems of traditional medicine in South Asia. In particular, Oxystelma esculentum (often called “Safed Kamal” or "Milkweed") is cited in Ayurvedic and Unani texts for its purported anti-inflammatory, detoxifying, and skin-healing properties. Traditional healers have used the plant for a range of skin disorders, including eczema, dermatitis, and other forms of rash. The leaves and stems are sometimes applied topically as poultices or made into pastes, or extracts are used in bath preparations.

However, there is a lack of robust clinical or pharmacological studies directly validating its use for eczema. The justification for its application is based on longstanding traditional knowledge rather than systematic research. Some preliminary phytochemical analyses have identified saponins, flavonoids, and other compounds with general anti-inflammatory properties in the plant, but there are no peer-reviewed studies specifically assessing the efficacy or safety of Oxystelma for eczema in humans or animal models. Therefore, while its traditional use is documented, the scientific evidence supporting its effectiveness is minimal to none.