Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mahonia species, particularly Mahonia aquifolium (Oregon grape), have been investigated for their potential in treating eczema, especially atopic dermatitis. The evidence supporting their use is primarily scientific, with a moderate level of support. Several clinical studies and reviews have evaluated topical Mahonia extracts and ointments for inflammatory skin conditions. The plant contains alkaloids such as berberine, which exhibit anti-inflammatory, antimicrobial, and antiproliferative effects. A randomized, double-blind, placebo-controlled trial published in the Journal of the American Academy of Dermatology (2005) found that Mahonia aquifolium cream significantly improved symptoms of mild-to-moderate atopic dermatitis compared to placebo. Other smaller studies and case series also report beneficial effects, particularly in reducing redness, scaling, and itching.

Despite these positive findings, the overall quality and quantity of clinical evidence are moderate, with some studies having small sample sizes or methodological limitations. There is a lack of large-scale, multicenter randomized controlled trials. Mahonia is also traditionally used in herbal medicine for skin conditions, but its modern use for eczema relies mostly on scientific investigation. Safety profiles from clinical studies are generally favorable, with mild and infrequent adverse reactions reported. In summary, Mahonia shows promise as a supportive treatment for eczema, but more robust clinical data are needed to firmly establish its efficacy and optimal usage.

More about Mahonia (unspecified)
More about Eczema

Other ingredients used for Eczema

Other health conditions supported by Mahonia (unspecified)

Products containing Mahonia (unspecified)