Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a naturally occurring flavonoid found in many fruits, vegetables, and herbs. Its use in supporting or treating eczema (atopic dermatitis) is primarily based on its anti-inflammatory and antioxidant properties, which have been demonstrated in several preclinical (cell and animal) studies. Luteolin inhibits the release of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α, which are known to play key roles in the pathogenesis of eczema. In in vitro studies, luteolin has been shown to suppress mast cell activation, which is significant because mast cells contribute to the inflammatory and allergic responses seen in eczema.

A few small clinical studies and case reports have explored the topical application of creams containing luteolin (often in combination with other flavonoids) in patients with atopic dermatitis, showing some reduction in itching, redness, and inflammation. However, these studies are limited in size and often lack rigorous controls, making it difficult to draw definitive conclusions. There is also preliminary evidence suggesting that oral supplementation with luteolin may modulate immune responses and reduce allergic inflammation, but high-quality human trials are lacking.

In summary, while luteolin shows promise based on its biological activities and early experimental studies, the direct clinical evidence for its effectiveness in treating eczema is limited. Therefore, the current level of scientific support is modest (rated 2 out of 5). Further well-designed clinical trials are needed to determine its true efficacy and safety in eczema management.

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