Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactiplantibacillus plantarum is a probiotic bacterium that has been studied for its potential benefits in atopic dermatitis (eczema), though evidence is still emerging and overall remains limited. Some scientific studies, including small randomized controlled trials and animal studies, suggest that supplementation with L. plantarum may help modulate the immune system and improve skin barrier function, both of which are implicated in eczema pathophysiology.

Several human trials have investigated the effects of L. plantarum on eczema, particularly in children. For example, a double-blind, placebo-controlled trial published in Pediatric Allergy and Immunology (2012) found a modest improvement in eczema severity scores in children who received L. plantarum supplementation compared to placebo. The proposed mechanisms include the enhancement of regulatory T cell activity, reduction of inflammatory cytokines, and modulation of gut microbiota, which in turn may reduce systemic inflammation associated with atopic dermatitis.

However, the clinical evidence remains inconsistent, with some studies showing no significant benefit. Systematic reviews and meta-analyses note that while certain probiotics may offer some benefit for eczema, the effect size is typically small and strain-specific, and the quality of evidence is low to moderate. Currently, guidelines from major dermatology organizations do not universally recommend probiotics, including L. plantarum, as standard therapy for eczema due to insufficient robust evidence.

In summary, while there is some scientific rationale and preliminary evidence for the use of L. plantarum in supporting eczema, the evidence base is not strong, and further high-quality studies are needed.

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