Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Iridoid glycosides, a class of phytochemicals found in various medicinal plants such as Plantago, Verbena, and Scrophularia species, have a history of traditional use for treating inflammatory skin conditions, including eczema. In traditional herbal medicine, especially in Europe and parts of Asia, preparations containing iridoid glycoside-rich plants have been topically applied or taken orally to reduce skin inflammation, itching, and irritation. The rationale for their use is primarily anecdotal, based on folk medicine practices rather than rigorous clinical trials.

Scientific studies on iridoid glycosides themselves are limited with respect to eczema specifically. Some in vitro and animal studies suggest that iridoid glycosides possess anti-inflammatory and antioxidant properties, which could theoretically be beneficial in inflammatory skin disorders. For example, aucubin and catalpol, two well-known iridoid glycosides, have shown anti-inflammatory effects in laboratory models. However, direct clinical trials investigating their efficacy in eczema patients are lacking, and most evidence comes from broader studies on their anti-inflammatory actions rather than eczema-specific research.

In summary, the use of iridoid glycosides for eczema is primarily supported by traditional usage rather than strong scientific validation. The current level of evidence is limited, and while their general anti-inflammatory potential is promising, more research is required to establish efficacy and safety for eczema treatment specifically.

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