Holarrhena, particularly Holarrhena antidysenterica, is a plant widely used in Ayurvedic and other traditional systems of medicine, primarily for the treatment of gastrointestinal disorders such as dysentery and diarrhea. Its use for skin conditions, including eczema, is less common but is sometimes mentioned in traditional herbal compendia and ethnobotanical literature. In these contexts, Holarrhena seeds or bark may be applied topically or taken internally as part of polyherbal formulations aimed at alleviating skin inflammation, itching, or eruptions. The rationale in traditional medicine is often based on the plant's reputed anti-inflammatory and antimicrobial properties.

However, scientific evidence supporting Holarrhena's efficacy in treating eczema is minimal. There are a few laboratory studies exploring the anti-inflammatory or antimicrobial activities of Holarrhena extracts, but these are generally not specific to eczema or dermatitis models, nor have they advanced to clinical trials in humans for this indication. No robust clinical studies or systematic reviews currently validate the effectiveness of Holarrhena for eczema. Therefore, its use for this condition is justified mainly by traditional precedent rather than modern scientific validation.