Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a diverse group of phytonutrients found in many fruits, vegetables, and plant-based foods, known for their antioxidant and anti-inflammatory properties. Their use in managing eczema (atopic dermatitis) is primarily supported by preclinical and some early clinical evidence, rather than traditional or folkloric usage. Laboratory studies have demonstrated that certain flavonoids, such as quercetin, luteolin, and apigenin, can modulate inflammatory pathways, inhibit histamine release, and reduce oxidative stress in cellular and animal models relevant to eczema. For example, quercetin has been shown to suppress Th2 cytokines, which are implicated in the pathology of atopic dermatitis. Some small clinical studies and pilot trials have explored the use of flavonoid-rich extracts (such as from licorice root or chamomile) topically or orally, reporting modest improvements in eczema symptoms, including reduced itching and inflammation. However, large, rigorous clinical trials are lacking, and the evidence base remains limited in scope and quality. Current dermatological guidelines do not routinely recommend flavonoids as a primary treatment for eczema, but they are sometimes included as adjuncts in integrative or complementary approaches. In summary, the scientific rationale for flavonoid use in eczema is supported by mechanistic and some preliminary clinical data, but robust evidence from high-quality human trials is still needed.

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