Ficus simplicissima is primarily used in traditional medicine systems in parts of Asia for a variety of skin ailments, including eczema. Ethnobotanical surveys and records from Vietnam, Thailand, and China document its use as a topical treatment for skin disorders, leveraging the plant's purported anti-inflammatory and soothing properties. Preparations often involve using the leaves or latex of the plant, applied directly to affected areas.

However, there is a lack of robust scientific validation for these uses. While related species in the Ficus genus have shown some anti-inflammatory and antimicrobial properties in preliminary laboratory studies, there are no high-quality clinical trials or rigorous pharmacological studies specifically investigating Ficus simplicissima for eczema. The available evidence is thus mainly anecdotal and based on traditional practices rather than modern research.

In summary, the use of Ficus simplicissima for eczema is rooted in traditional medicine, but current scientific evidence to substantiate its efficacy or safety for this condition is minimal.