Ceramides are a class of lipid molecules naturally found in the stratum corneum, the outermost layer of the skin. Scientific evidence supports their role in maintaining the skin barrier and retaining moisture. In individuals with eczema (atopic dermatitis), studies consistently show that ceramide levels are significantly reduced, contributing to impaired skin barrier function, increased transepidermal water loss, and heightened sensitivity to irritants and allergens.

Topical products containing ceramides have been evaluated in multiple randomized controlled trials and clinical studies. These studies demonstrate that ceramide-containing moisturizers can help restore the skin barrier, reduce eczema severity, and decrease the need for topical corticosteroids. Notably, guidelines from dermatological organizations, including the American Academy of Dermatology, recommend ceramide-based therapies as part of the management of eczema, especially for maintenance and prevention of flare-ups.

While ceramide products do not address the underlying immunological causes of eczema, their barrier-repairing properties are well-supported by biochemical and clinical research. Overall, the use of ceramides in eczema management is grounded in robust scientific evidence and is considered a standard component of skincare for this condition.