Psacalium peltatum, commonly known as "Matarique," is used in traditional medicine, particularly in Mexico and parts of Central America, to address a variety of ailments, including dyspepsia (indigestion). Historical ethnobotanical literature documents its use by indigenous groups and traditional healers for gastrointestinal complaints, including stomach pain, indigestion, and as a general digestive aid. The plant is reputed to possess carminative and stomachic properties, which may help alleviate symptoms like bloating and discomfort associated with dyspepsia.

However, scientific validation of these effects is limited. While a few preliminary phytochemical studies have identified the presence of sesquiterpene lactones and other compounds with potential biological activity in Psacalium peltatum, there is a lack of rigorous clinical trials or pharmacological studies specifically evaluating its efficacy or safety for dyspepsia. Most of the available evidence is anecdotal or based on traditional knowledge rather than modern scientific research.

In summary, the use of Psacalium peltatum for dyspepsia is primarily supported by traditional practices rather than robust scientific evidence. Its rating reflects the presence of a well-documented ethnomedical history but a lack of high-quality, modern research to substantiate its effectiveness or safety for this indication.