Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata, an herb widely used in traditional medicine, particularly in Southeast Asia and India. The plant, often referred to as "King of Bitters," has a long history of use for a variety of ailments, including digestive disorders such as dyspepsia (indigestion). Traditional Ayurvedic and Chinese medicine systems have recommended extracts of Andrographis paniculata for symptoms like loss of appetite, bloating, and general stomach discomfort, which fall under the umbrella of dyspepsia. The bitter principle of the plant, attributed in part to neoandrographolide, is believed in traditional medicine to stimulate digestive secretions and improve digestion.

From a scientific perspective, direct clinical evidence specifically evaluating neoandrographolide for dyspepsia is limited or lacking. Most available studies focus on the whole plant extract or other major constituents like andrographolide, and these studies are often preclinical or of low methodological quality. There is some evidence that bitter compounds can promote gastric secretions and motility, but robust clinical trials supporting neoandrographolide or Andrographis paniculata for dyspepsia are sparse. Therefore, its use for dyspepsia is primarily justified by traditional practices rather than strong scientific validation.

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