Evidence supporting the use of: Goldenseal
For the health condition: Dyspepsia

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of use in traditional herbal medicine, particularly among Native American tribes and later in 19th-century Western herbalism. It was commonly used as a remedy for various digestive complaints, including dyspepsia (indigestion). The traditional rationale stems from its presumed ability to stimulate digestive secretions, improve appetite, and relieve discomfort associated with poor digestion. These uses were largely based on empirical observation rather than controlled scientific studies.

Goldenseal contains active compounds such as berberine, hydrastine, and canadine, which exhibit antimicrobial and anti-inflammatory properties. Some in vitro and animal studies suggest berberine may have beneficial effects on gut motility and microbial balance, but direct clinical evidence for goldenseal’s efficacy in treating dyspepsia in humans is very limited. No large-scale, well-controlled human trials have confirmed its benefits specifically for dyspepsia. Thus, its use for this purpose remains based primarily on traditional use and anecdotal reports rather than robust scientific validation.

In summary, goldenseal’s use for dyspepsia is rooted in traditional herbal medicine and lacks strong clinical evidence. While there are plausible mechanisms of action based on its phytochemistry, current scientific support is weak, warranting a modest evidence rating.

More about goldenseal
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