Centipeda minima (commonly known as "Small Sneezeweed") has a long history of use in traditional Chinese medicine (TCM) and other traditional medicinal systems, particularly in East and Southeast Asia. It is often included in herbal formulas aimed at relieving symptoms of dyspepsia, such as bloating, poor appetite, and abdominal discomfort. In TCM, Centipeda minima is thought to "regulate Qi" and "harmonize the stomach," theoretical concepts that have guided its use for digestive complaints for centuries.

However, scientific evidence directly supporting the efficacy of Centipeda minima for dyspepsia is limited. A few pharmacological studies have identified components such as sesquiterpene lactones and flavonoids with potential anti-inflammatory and antioxidant effects, but these studies rarely focus on dyspepsia specifically. Most of the available data are either in vitro or animal studies, and clinical trials in humans for dyspepsia are lacking.

Therefore, while Centipeda minima is used traditionally for digestive issues including dyspepsia, and some of its bioactive compounds could theoretically contribute to gastrointestinal health, its use for this purpose is primarily justified by tradition rather than robust scientific validation.