Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Artichoke (Cynara scolymus) leaf extract is used to support and treat dyspepsia, and this use is justified by both traditional and scientific evidence. Traditionally, artichoke leaves have been used in European herbal medicine as a remedy for digestive ailments, including indigestion and dyspepsia. The rationale is based on its cholagogue and choleretic properties—meaning it stimulates bile production and flow, which aids fat digestion and can reduce symptoms like bloating, nausea, and abdominal discomfort.

Scientific validation exists for this traditional use. Several randomized, placebo-controlled clinical trials have evaluated standardized artichoke leaf extract in patients with functional dyspepsia. For example, a double-blind study published in Alimentary Pharmacology & Therapeutics (2003) found significant improvement in dyspeptic symptoms (such as fullness, bloating, and abdominal pain) in patients taking artichoke extract compared to placebo. Other studies, including a large open-label trial in Germany, have reported similar benefits. Meta-analyses and systematic reviews acknowledge modest but consistent improvements in global dyspepsia symptoms.

The proposed mechanisms involve artichoke’s ability to stimulate bile secretion, enhance lipid digestion, and possibly exert antispasmodic and antioxidant effects in the gastrointestinal tract. Though results are generally positive, some studies suggest the effect size is moderate; hence, the evidence is rated as 3 out of 5. Overall, artichoke leaf extract is a well-tolerated option with a reasonable scientific basis for supporting digestive comfort in dyspepsia.

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