Evidence supporting the use of: Folate
For the health condition: Down Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Folate (vitamin B9) supplementation in individuals with Down syndrome is primarily justified by scientific reasoning, though the strength of evidence supporting clinical benefits is limited. Down syndrome is associated with disturbances in the folate/homocysteine metabolic pathway, often resulting in abnormal methylation status and potential increased risk of certain medical complications. Some studies have documented that people with Down syndrome may have altered folate metabolism due to overexpression of genes on chromosome 21, including cystathionine-beta-synthase, which can impact homocysteine and folate levels.

Based on these biochemical findings, folate supplementation has been proposed as a way to support proper methylation processes and potentially ameliorate some cognitive or developmental issues, as well as reduce homocysteine, a risk factor for vascular disease. However, clinical trials have generally not shown significant improvements in cognitive function with folate or related B-vitamin supplementation in people with Down syndrome. The evidence base is largely biochemical and theoretical, rather than demonstrating clear, reproducible clinical benefits.

Nonetheless, folate remains important for general health, and individuals with Down syndrome should receive adequate dietary intake to avoid deficiency. Some clinicians may recommend supplementation for specific cases of deficiency or elevated homocysteine, but routine high-dose folate supplementation as a therapy for Down syndrome itself is not strongly supported by current scientific evidence.

More about folate
More about Down Syndrome

Other ingredients used for Down Syndrome

acetyl l-carnitine
folate
green tea