Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium is an essential mineral involved in numerous biochemical processes in the human body, including roles in neuromuscular transmission and neurotransmitter regulation. With respect to the dopamine system specifically, some scientific studies suggest that magnesium may influence dopaminergic signaling. For example, magnesium has been shown in animal studies to modulate dopamine receptor activity and to protect against dopamine neuron dysfunction. In humans, low magnesium levels have been associated with neuropsychiatric symptoms such as depression and anxiety, conditions that are partially linked to dopamine dysregulation. However, direct clinical evidence for magnesium supplementation enhancing dopamine function or treating dopamine-related disorders is limited and mostly indirect. While magnesium deficiency may contribute to neurological symptoms through multiple pathways, including impaired dopamine synthesis or signaling, robust randomized controlled trials in humans are lacking. Thus, while there is a plausible biological rationale and some supporting preclinical data, the clinical effectiveness of magnesium specifically for supporting the dopamine system remains inadequately substantiated.

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