Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Sennosides are stimulant laxatives derived from the senna plant and are widely used in both adults and children to treat constipation. Their use in pediatric constipation is supported by substantial clinical evidence and established guidelines. Sennosides work by irritating the lining of the bowel, thereby stimulating intestinal motility and promoting water secretion into the colon, which helps soften stools and facilitate bowel movements.

Multiple clinical studies and reviews have evaluated the efficacy and safety of sennosides in children. For example, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) include stimulant laxatives such as sennosides as part of their recommended protocols for treating functional constipation in children, particularly for short-term use or when other agents are ineffective. Evidence indicates that sennosides are effective in increasing stool frequency and improving symptoms of constipation in the pediatric population. However, their use should be judicious and typically reserved for cases where first-line osmotic laxatives (like polyethylene glycol) are insufficient, due to the potential for side effects such as abdominal cramping and, with long-term use, risk of dependence.

In summary, the use of sennosides to treat constipation in children is backed by scientific evidence and is included in widely accepted clinical guidelines, though careful monitoring and short-term use are recommended.

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