Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Methylcellulose is a synthetic bulk-forming laxative widely used to manage constipation, including in children. Its use is scientifically validated, though most robust evidence comes from adult populations. Methylcellulose works by absorbing water in the intestine, increasing stool bulk and moisture, thereby promoting peristalsis and easier defecation. Several clinical guidelines (e.g., NICE, NASPGHAN/ESPGHAN) mention bulk-forming agents such as methylcellulose as options for pediatric constipation, although they are generally considered second-line after osmotic or stimulant laxatives. Published studies directly evaluating methylcellulose in children are limited, but its mechanism of action is well-understood and safety profile is favorable, provided adequate hydration is maintained. Evidence supporting its efficacy in children is derived from its established use in adults and extrapolation from related fiber laxatives. Side effects are uncommon but can include bloating and abdominal discomfort. In summary, there is moderate scientific support for methylcellulose in pediatric constipation, primarily based on its pharmacological rationale and clinical experience, but high-quality pediatric-specific randomized controlled trials are lacking.

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