Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Hydroxyanthracene derivatives, such as those found in senna, cascara, and aloe, have a long history of traditional use as stimulant laxatives to treat constipation, including in children. These compounds act by stimulating colonic motility and altering water and electrolyte secretion, thereby promoting bowel movements. Historical records and traditional pharmacopeias, particularly in Ayurvedic and European herbal medicine, have described the use of hydroxyanthracene-containing plants for constipation relief over centuries.

However, while their use is well established in traditional medicine, scientific validation for their safety and efficacy in children is limited. Most clinical studies have focused on adult populations, and pediatric data are sparse. Modern clinical guidelines generally recommend other first-line therapies (such as dietary fiber or osmotic laxatives) for childhood constipation due to concerns regarding potential side effects, including abdominal pain, cramping, and the risk of dependency with prolonged use of stimulant laxatives.

Thus, while hydroxyanthracene derivatives are traditionally used for constipation, especially in adults, their use in children is supported by tradition rather than robust scientific evidence. Regulatory agencies in Europe have even cautioned against their use in the pediatric population, citing insufficient safety data. In summary, the use of hydroxyanthracene for childhood constipation is primarily based on historical practice, with limited scientific support and safety concerns restricting its routine pediatric use.

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