Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Frangula (commonly known as buckthorn bark or Frangula alnus) has a long-standing history of use as an herbal remedy for constipation, including in children. The use is primarily justified by traditional herbal medicine, especially in Europe. It contains compounds called anthraquinone glycosides, which are chemically similar to those found in senna and cascara sagrada, other well-known herbal laxatives. In the colon, these compounds are metabolized by bacteria to active forms that stimulate peristalsis and reduce water absorption, resulting in a laxative effect. However, scientific studies specifically evaluating the safety and efficacy of Frangula in children are limited or lacking. Most safety data and clinical trials for anthraquinone laxatives focus on adults. Concerns have also been raised about the potential for abdominal cramping, dependency, and electrolyte disturbance with long-term use. As a result, while Frangula has been traditionally used for constipation, including in pediatric contexts, its use in children is not well-supported by modern clinical research, and it is generally not recommended for children in contemporary medical guidelines. Therefore, the evidence rating is moderate (2), reflecting traditional use but a lack of substantial scientific validation for pediatric use.

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