Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Clostridium butyricum is a probiotic bacterium that has been studied for its role in gastrointestinal health, including the treatment of constipation in children. The scientific rationale for its use is based on its ability to produce short-chain fatty acids, particularly butyrate, which can promote intestinal motility and improve stool consistency. Several clinical studies, particularly from East Asia, have evaluated C. butyricum as an adjunct or alternative to traditional laxatives in pediatric populations. For example, randomized controlled trials have reported improvements in stool frequency and consistency among children with functional constipation who received C. butyricum preparations compared to placebo. The proposed mechanisms include modulation of gut microbiota composition, anti-inflammatory effects, and enhancement of mucosal barrier function.

Despite these promising findings, the overall quality of evidence is moderate. Many studies are small, have methodological limitations, or are limited to specific populations. Meta-analyses and systematic reviews generally conclude that while C. butyricum shows potential benefit, larger and more rigorous trials are needed. International guidelines do not routinely recommend C. butyricum as a first-line therapy for childhood constipation, but acknowledge probiotics as a possible adjunct in refractory cases. In summary, the use of C. butyricum for pediatric constipation is supported by a growing body of scientific literature, though further high-quality research is warranted to establish its efficacy and safety profile.

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