Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthraquinone derivatives, particularly those found in natural products such as senna (sennosides) and cascara, are well-established stimulant laxatives. Their use for constipation, including in children, is based on both historical (traditional) and scientific evidence, but the scientific validation is substantial, especially for the purified, standardized compounds. Anthraquinones act by stimulating colonic motility and reducing water absorption in the colon, which facilitates bowel movements.

Clinical guidelines—including those from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)—acknowledge the use of sennosides, which are anthraquinone glycosides, as a second-line therapy for pediatric constipation when osmotic laxatives are insufficient. Several clinical studies and systematic reviews support their short-term efficacy in treating pediatric constipation. However, the use of anthraquinone-containing agents in children should be carefully monitored, as their overuse can cause abdominal cramping, diarrhea, and, rarely, electrolyte disturbances. Long-term safety data in children are limited, and guidelines generally recommend restricting use to short durations.

In summary, anthraquinone derivatives have a scientifically supported role as stimulant laxatives for the treatment of constipation in children, primarily as a short-term solution when other agents fail. Their effectiveness is supported by clinical evidence, but there are important safety considerations and limitations on duration of use.

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