Sichuan Fritillary, known as Chuan Bei Mu (川贝母) in Traditional Chinese Medicine (TCM), has a long history of use for respiratory issues, particularly to address symptoms like cough and phlegm that often accompany sinus congestion. In TCM, Chuan Bei Mu is classified as an herb that "transforms phlegm and stops cough," and it is commonly prescribed for conditions characterized by thick, stubborn mucus, including sinus congestion. The herb is believed to moisten the lungs, clear heat, and dissolve phlegm, which indirectly alleviates congestion in the upper respiratory tract, including the sinuses.

Despite its widespread traditional use, scientific research specifically validating Sichuan Fritillary for sinus congestion is limited. Most available studies focus on its general expectorant and antitussive (cough-suppressing) properties. Some laboratory and animal studies have suggested that alkaloids found in Fritillaria species possess anti-inflammatory and mucus-reducing effects, which could conceivably help sinus congestion, but clinical evidence in humans is lacking. Therefore, while the traditional use is well-documented and some pharmacological activities are promising, robust scientific validation for its use specifically in sinus congestion is minimal.