Evidence supporting the use of: Exphedrine HCl
For the health condition: Congestion (sinus)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Ephedrine HCl is scientifically validated for use in the treatment of nasal and sinus congestion. Ephedrine is a sympathomimetic amine that acts by stimulating alpha and beta-adrenergic receptors, leading to vasoconstriction of the blood vessels in the nasal mucosa. This vasoconstriction reduces swelling and congestion in the nasal passages and sinuses, making breathing easier. Ephedrine's decongestant properties have been well-documented in pharmacological and clinical studies since the early 20th century. It was a mainstay in over-the-counter decongestant products before the emergence of other agents such as pseudoephedrine and phenylephrine. Clinical guidelines and pharmacology references (e.g., Goodman & Gilman’s The Pharmacological Basis of Therapeutics) describe ephedrine's efficacy in reducing nasal congestion, especially when administered orally or in inhaled form. However, due to concerns regarding potential side effects (e.g., elevated blood pressure, CNS stimulation, risk of misuse), its use has become more restricted or regulated in many countries. Nonetheless, its mechanism and clinical effect on nasal congestion are well established and supported by a strong body of scientific evidence.

More about Exphedrine HCl
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Products containing Exphedrine HCl

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