Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Laggera pterodonta is traditionally used in several regions of Africa and Asia to treat colds accompanied by fever. Ethnobotanical surveys report that indigenous practitioners in Ethiopia, Nigeria, and parts of China commonly prepare infusions or decoctions of the plant, particularly its leaves, for patients exhibiting symptoms of upper respiratory tract infections, including fever, cough, and nasal congestion. The rationale behind its use is rooted in its perceived antipyretic (fever-reducing), anti-inflammatory, and antimicrobial properties, as described in traditional medical texts and local knowledge systems.

Preliminary phytochemical studies indicate that Laggera pterodonta contains sesquiterpenoids and flavonoids, which may have anti-inflammatory and immunomodulatory effects. Some in vitro and animal model studies have shown extracts of the plant possess mild antipyretic and antimicrobial activities. However, there is limited direct clinical evidence in humans to substantiate these effects or confirm its efficacy and safety for treating colds with fever.

In summary, the use of Laggera pterodonta for colds with fever is primarily justified on traditional grounds, supported by some in vitro and preclinical pharmacological findings but lacking robust clinical trials. Its evidence rating is moderate (3) due to the prevalence of traditional use and preliminary scientific interest, but the lack of controlled human studies limits a higher rating.

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