Evidence supporting the use of: Indigo leaves
For the health condition: Colds (with fever)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Indigo leaves (from the plant Indigofera tinctoria and related species) have a long history of use in traditional medicine systems, particularly in South and Southeast Asia. In various folk remedies, indigo leaves have been used to manage symptoms of colds, especially those accompanied by fever. Traditional healers often prepare decoctions or infusions from indigo leaves, attributing antipyretic (fever-reducing) and anti-inflammatory effects to the plant. However, the evidence supporting these uses is largely anecdotal and rooted in ethnobotanical practices rather than rigorous scientific research.

Modern pharmacological studies on indigo leaves are limited, but some preliminary research suggests the presence of compounds with antimicrobial and anti-inflammatory properties, such as indirubin. These studies, however, are mostly in vitro or in animal models, and direct clinical evidence for treating colds or fever in humans is lacking. Therefore, while traditional use exists and is recognized in some herbal medicine compendia, scientific validation is minimal. The evidence rating of 2 reflects that indigo leaves are traditionally used for this purpose, but strong scientific support is not available to justify its efficacy or safety for treating colds with fever.

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