Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Baphicacanthus cusia (commonly known as "Qing Dai" or "Indigo Naturalis") has a long-standing history of use in traditional Chinese medicine (TCM) for the treatment of colds, particularly those accompanied by fever. In TCM, Baphicacanthus cusia is considered to have "heat-clearing" and "detoxifying" properties, and is often prescribed for febrile diseases, sore throat, and various infectious conditions. The plant is typically used either alone or in combination with other herbs in decoctions, powders, or topical preparations.

Historically, Qing Dai was included in classical Chinese herbal formulas designed to address symptoms resembling those of modern viral upper respiratory tract infections—such as fever, sore throat, and inflammation. The rationale for its use stemmed from empirical observations and TCM theory rather than modern biomedical evidence. While some recent pharmacological studies suggest Baphicacanthus cusia extracts possess anti-inflammatory, antiviral, and immunomodulatory effects, these findings are preliminary and largely based on in vitro or animal studies. Specifically, indigo and indirubin—active compounds in B. cusia—have demonstrated anti-inflammatory activity, but direct clinical evidence for efficacy in treating colds with fever in humans remains limited.

In summary, the use of Baphicacanthus cusia for colds with fever is primarily justified by traditional use, with moderate support from early pharmacological research but without robust clinical trials to firmly validate its effectiveness for this indication.

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