Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a sesquiterpene compound found in Atractylodes species, such as Atractylodes macrocephala and Atractylodes lancea, which are prominent herbs in traditional Chinese medicine (TCM). In TCM, these herbs have been used for centuries to support the body's response to colds, especially those accompanied by fever. They are often included in herbal formulas aimed at dispelling "dampness" and strengthening the "spleen," concepts relevant to TCM's understanding of how the body resists external pathogens like those causing colds. Atractylone is considered one of the main active components responsible for some of the herb's effects. Modern pharmacological research provides limited support for these traditional uses. Some in vitro and animal studies suggest that atractylone and Atractylodes extracts may have anti-inflammatory, immunomodulatory, and possibly mild antiviral effects. For example, atractylone has shown the ability to modulate cytokine production and inhibit inflammatory pathways in experimental settings. However, direct clinical evidence supporting the use of atractylone or Atractylodes extracts for treating colds with fever in humans is lacking. Most evidence remains preclinical, and robust human trials are absent. In summary, the use of atractylone for colds with fever is justified primarily by traditional use in TCM, with a modest amount of preliminary scientific evidence (rated 2/5) that hints at potential mechanisms but is far from conclusive or clinically validated.

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